Patterns and Mechanisms of Diminishing Returns from Beneficial Mutations
نویسندگان
چکیده
منابع مشابه
Diminishing returns epistasis among beneficial mutations decelerates adaptation.
Epistasis has substantial impacts on evolution, in particular, the rate of adaptation. We generated combinations of beneficial mutations that arose in a lineage during rapid adaptation of a bacterium whose growth depended on a newly introduced metabolic pathway. The proportional selective benefit for three of the four loci consistently decreased when they were introduced onto more fit backgroun...
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Adaptive evolution ultimately is fuelled by mutations generating novel genetic variation. Non-additivity of fitness effects of mutations (called epistasis) may affect the dynamics and repeatability of adaptation. However, understanding the importance and implications of epistasis is hampered by the observation of substantial variation in patterns of epistasis across empirical studies. Interesti...
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Because adaptation depends upon the fixation of novel beneficial mutations, the fitness effects of beneficial mutations that are substituted by selection are key to our understanding of the process of adaptation. In this study, we experimentally investigated the fitness effects of beneficial mutations that are substituted when populations of the pathogenic bacterium Pseudomonas aeruginosa adapt...
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"The Law of Diminishing Returns" (Spearman, 1927) states that the size of the average correlation between cognitive tasks tends to be relatively small in high ability groups and relatively high in low ability groups. Studies supporting this finding have tended to contrast very low ability subjects (IQ < 78) with subjects from higher ability ranges and to use tests that have poor discriminatory ...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2019
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/msz035